Inhalation 1-2-3 A brief update from Inhaltion Magazine.

Inhalation-grade capsules for use in dry powder inhalers
imageCapsules used in dry powder inhalers (DPIs) must provide good aerosolization and drug delivery. In addition, powders should empty from the capsule shell with minimum retention. Capsule moisture content and the degree of capsule mold pin lubricant have a direct influence on these properties. Controlling the internal lubricant content is essential for good performance. In contrast, lack of control can lead to high surface roughness, which in turn could increase powder adherence in the capsule and decrease aerosolization.

Inhalation-grade, plant-based capsules can provide an excellent option for use with dry powder inhalers. With good mechanical properties, low moisture content compared with gelatin capsules, and a controlled, lubricated surface, these vegetal-origin capsules can provide good powder emptying, drug delivery and aerosolization.

Qualicaps® Europe, S.A.U.
Spain: +34 91 6 63 0 800
in focus

imageLocal treatment of non-small-cell lung cancer (NSCLC) by dry powder inhaler
Local treatment of lung cancer by the inhalation route is an emerging therapeutic area, particularly for early stages of the disease when the cancer is localized in the lung tissue. This article outlines manufacturing and formulation considerations for local treatment of lung cancer by dry powder inhaler. Using spray drying to engineer respirable particles, three case studies demonstrate the broad applicability of this technology to small and large molecules alike. These studies include:
  • Dry powder gemcitabine with excipient-enhanced growth
  • Inhaled bevacizumab dry powder reduces tumor burden in NSCLC rat model
  • Inhalable bevacizumab/small molecule dry powder combination therapies for NSCLC
Looking forward, future clinical trials for local treatment of lung cancer by dry powder inhaler hold great promise for patients of this challenging disease.

imageDry powder inhalers—More than 170 years of development; Where to next? and Dry powder inhalers: A new look at what may be next
In an initial article, the authors provide a brief history of dry powder inhalers including the earliest reference to therapeutic dry powder inhalation that may also be the earliest reference to "engineered particles," dating from 1849, in London. Other examples include the first recognized pharmaceutical dry powder for inhalation, introduced by Abbott Laboratories in the late 1940s. Another landmark was the Spinhaler® from Fisons Limited, which provided increased dosing capacity and addressed the patient's need for coordinated actuation and inhalation. The article also discusses considerations for future development such as formulation, dose storage, moisture protection and metering, de-aggregative processes, counters, the environment, patient considerations and non-respiratory indications. Then, a new interview considers current challenges and opportunities for DPIs, including ways dry powder inhalers (DPIs) might improve patient technique, patient adherence, smart inhalers and delivery of biologics.
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